There is a problem with viewing pop-up facts with pause. Sometimes during a cutscene, the game would just pause for no reason without any pop-up facts. The continue key for pop-up dismissal also would not work. I had to press pause on the keyboard to continue and the cutscene would get skipped. I am not sure if this problem was present in older PCs as I have only noticed it on my current Windows 10 PC.
The game does not run smoothly on my newer Windows 10 PC. Every 2-3 minutes the game would pause for about 1 second and the HDD light would be on. I definitely did not have this problem on my older Windows 7 PC.
Sometimes the CTRL and ALT keys would stop responding. A quick fix is to ALT-Tab out of the game and then back in. These are the default keys for crouch lower and aim through iron sights/scope.